Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.37 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446187 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL1040508 | 0.96 | TSHR (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Iodide SCHEMBL4843397 | 0.96 | TSHR (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Acetic Acid SCHEMBL4442312 | 0.92 | TSHR (0.47) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL28390981 | 0.83 | TSHR (0.39) | TSHRZDHHC20ZDHHC2 | |
| SCHEMBL108995 | 0.78 | — | — | |
| SCHEMBL1065203 | 0.78 | TSHR (0.54) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL22868489 | 0.78 | TSHR (0.54) | TSHRALDH1A1MAPK1TDP1CYP2C19 | |
| SCHEMBL11169697 | 0.77 | ZDHHC20 (0.49) | TSHRALDH1A1MAPK1ZDHHC20ZDHHC2 | |
| SCHEMBL176143 | 0.76 | TSHR (0.52) | TSHRALDH1A1MAPK1TDP1ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051861-A1 | POROUS MEMBRANE AND RECORDING MEDIA COMPRISING SAME | FUJIFILM Manufacturing Europe B.V. (NL) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008016303-A1 | POROUS MEMBRANE AND RECORDING MEDIA COMPRISING SAME | FUJIFILM MANUFACTURING EUROPE B.V. (NL) | 2008-02-07 | — | — | WO | disclosed |