Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.37 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446187 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL1040508 | 0.96 | TSHR (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Bromide SCHEMBL4449404 | 0.96 | TSHR (0.50) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| Acetic Acid SCHEMBL4442312 | 0.92 | TSHR (0.47) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL28390981 | 0.83 | TSHR (0.39) | TSHRZDHHC20ZDHHC2 | |
| SCHEMBL22868489 | 0.78 | TSHR (0.54) | TSHRALDH1A1MAPK1TDP1CYP2C19 | |
| SCHEMBL11169697 | 0.77 | ZDHHC20 (0.49) | TSHRALDH1A1MAPK1ZDHHC20ZDHHC2 | |
| SCHEMBL176143 | 0.76 | TSHR (0.52) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL5170699 | 0.76 | TSHR (0.56) | TSHRALDH1A1MAPK1TDP1ZDHHC20 | |
| SCHEMBL108348 | 0.76 | TSHR (0.56) | TSHRALDH1A1MAPK1TDP1ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1714003-B1 | WELL BORE SERVICING FLUIDS COMPRISING THERMALLY ACTIVATED VISCOSIFICATION COMPOUNDS AND METHODS OF USING THE SAME | HALLIBURTON ENERGY SERVICES INC (US) | 2016-08-31 | — | — | EP | disclosed |
| US-7351681-B2 | Well bore servicing fluids comprising thermally activated viscosification compounds and methods of using the same | HALLIBURTON ENERGY SERVICES, INC. (US) | 2008-04-01 | — | — | US | disclosed |