Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441990 | 0.88 | P2RX7 (0.76) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL4442516 | 0.88 | P2RX7 (0.76) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL306699 | 0.85 | P2RX7 (0.78) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL306698 | 0.85 | P2RX7 (0.78) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL12702895 | 0.85 | P2RX7 (0.68) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL308204 | 0.82 | P2RX7 (0.63) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL308203 | 0.82 | P2RX7 (0.63) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL4443491 | 0.79 | P2RX7 (0.69) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL4440132 | 0.78 | P2RX7 (0.61) | P2RX7ENPP2 | |
| SCHEMBL306908 | 0.75 | P2RX7 (0.82) | P2RX7CSF1RPDGFRBPDGFRANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |