Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.61 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443575 | 0.91 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL4442516 | 0.91 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL4441990 | 0.91 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL4440942 | 0.86 | P2RX7 (0.57) | P2RX7 | |
| SCHEMBL4442126 | 0.84 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL305293 | 0.82 | P2RX7 (0.69) | P2RX7ANO1CACNA1HCACNA1GCACNA1I | |
| SCHEMBL27797216 | 0.82 | P2RX7 (0.69) | P2RX7ANO1CACNA1HCACNA1GCACNA1I | |
| SCHEMBL4449527 | 0.78 | P2RX7 (0.59) | P2RX7ENPP2 | |
| SCHEMBL306900 | 0.77 | P2RX7 (0.78) | P2RX7ANO1 | |
| SCHEMBL14407706 | 0.77 | P2RX7 (0.78) | P2RX7ANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | claimed |
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |