Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.76 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442516 | 1.00 | P2RX7 (0.76) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL4440132 | 0.91 | P2RX7 (0.61) | P2RX7 | |
| SCHEMBL4449527 | 0.88 | P2RX7 (0.59) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL4440942 | 0.87 | P2RX7 (0.57) | P2RX7 | |
| SCHEMBL307049 | 0.86 | P2RX7 (1.00) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL4443575 | 0.86 | P2RX7 (0.55) | P2RX7SCD | |
| SCHEMBL4442126 | 0.85 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL306977 | 0.84 | P2RX7 (0.84) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL305888 | 0.84 | P2RX7 (0.84) | P2RX7CSF1RPDGFRBPDGFRANTRK1 | |
| SCHEMBL305887 | 0.84 | P2RX7 (0.84) | P2RX7CSF1RPDGFRBPDGFRANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | claimed |
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |