Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.42 |
| ▸ | NMBR | P28336 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448716 | 0.90 | TACR1 (0.41) | SIRT2NMBR | |
| SCHEMBL1448717 | 0.77 | LMNA (0.41) | SIRT2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3573464 | 0.76 | SIRT2 (0.49) | SIRT2NMBRALDH1A1MEN1KMT2A | |
| Alcohol SCHEMBL6432975 | 0.75 | SIRT2 (0.47) | SIRT2NMBRALDH1A1 | |
| SCHEMBL4301302 | 0.72 | TACR1 (0.42) | SIRT2 | |
| SCHEMBL7713289 | 0.72 | SIRT2 (0.46) | SIRT2NMBRALDH1A1 | |
| SCHEMBL29221136 | 0.71 | ALDH1A1 (0.33) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL23278623 | 0.70 | SIRT2 (0.46) | SIRT2NMBRLMNA | |
| SCHEMBL14901171 | 0.70 | SIRT2 (0.46) | SIRT2NMBR | |
| SCHEMBL6777569 | 0.69 | SIRT2 (0.48) | SIRT2NMBRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131940-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |