Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | NMBR | P28336 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450314 | 0.90 | SIRT2 (0.42) | SIRT2NMBR | |
| SCHEMBL1448717 | 0.88 | LMNA (0.41) | TACR1SIRT2OPRD1OPRK1 | |
| SCHEMBL4301302 | 0.84 | TACR1 (0.42) | TACR1SIRT2OPRD1OPRK1CKS1B | |
| SCHEMBL14433203 | 0.81 | GPR119 (0.46) | — | |
| SCHEMBL22014536 | 0.80 | TACR1 (0.48) | TACR1OPRD1OPRK1 | |
| SCHEMBL7181950 | 0.76 | ACKR3 (0.45) | CKS1BSKP1SKP2 | |
| SCHEMBL947677 | 0.76 | KDM4E (0.49) | — | |
| SCHEMBL27688784 | 0.74 | TACR1 (0.41) | TACR1OPRD1OPRK1 | |
| SCHEMBL16445132 | 0.74 | GPR119 (0.41) | TACR1OPRD1OPRK1 | |
| SCHEMBL22770414 | 0.74 | POLB (0.46) | OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450332-B2 | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2297153-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009131940-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |