Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775938 | 0.80 | ALDH1A1 (0.52) | ALDH1A1CYP2A6MAPK1TDP1KDM4E | |
| SCHEMBL5202082 | 0.79 | TYR (0.47) | ALDH1A1HTTMAPK1KDM4ECYP3A4 | |
| SCHEMBL4731187 | 0.78 | TYR (0.49) | ALDH1A1MAPK1CYP3A4MAPTHPGD | |
| SCHEMBL26999431 | 0.78 | ACHE (0.58) | ALDH1A1CYP2A6MAPK1TDP1KDM4E | |
| SCHEMBL5188701 | 0.77 | MAPT (0.44) | ALDH1A1HTTMAPK1TDP1KDM4E | |
| SCHEMBL3955351 | 0.77 | MEN1 (0.51) | ALDH1A1MAPK1TDP1KDM4ECYP3A4 | |
| SCHEMBL3949877 | 0.76 | NQO2 (0.44) | ALDH1A1CYP2A6MAPK1TDP1KDM4E | |
| SCHEMBL4449667 | 0.74 | ACHE (0.39) | ALDH1A1CYP2A6MAPK1TDP1KDM4E | |
| SCHEMBL1515694 | 0.74 | ACP3 (0.56) | ALDH1A1CYP2A6CYP3A4MAPTCYP1A2 | |
| SCHEMBL5207565 | 0.74 | TYR (0.48) | ALDH1A1HTTMAPK1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074102-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008043567-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2008-04-17 | — | — | WO | disclosed |