Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949877 | 0.90 | NQO2 (0.44) | ACHEALDH1A1CYP2A6L3MBTL1MAPK1 | |
| SCHEMBL26999431 | 0.84 | ACHE (0.58) | ACHEALDH1A1CYP2A6L3MBTL1MAPK1 | |
| SCHEMBL4775938 | 0.84 | ALDH1A1 (0.52) | ACHEALDH1A1CYP2A6L3MBTL1MAPK1 | |
| SCHEMBL3945179 | 0.79 | ALDH1A3 (0.46) | ALDH1A1L3MBTL1MAPK1TDP1CYP3A4 | |
| SCHEMBL1515694 | 0.78 | ACP3 (0.56) | ALDH1A1CYP2A6L3MBTL1MAPTNPC1 | |
| SCHEMBL1420183 | 0.76 | LTA4H (0.53) | ALDH1A1CYP2A6MAPTRAB9AKDM4E | |
| SCHEMBL8057378 | 0.76 | MAPT (0.50) | ALDH1A1CYP2A6L3MBTL1MAPK1TDP1 | |
| SCHEMBL7456881 | 0.76 | HPGD (0.50) | ALDH1A1CYP2A6L3MBTL1MAPK1TDP1 | |
| SCHEMBL9992962 | 0.76 | APP (0.44) | ACHEALDH1A1CYP2A6L3MBTL1MAPK1 | |
| SCHEMBL1694896 | 0.76 | TDP1 (0.59) | ACHEALDH1A1CYP2A6L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074102-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008043567-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2008-04-17 | — | — | WO | disclosed |