Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.74 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450678 | 1.00 | MAPT (0.74) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL10849424 | 0.93 | MAOA (0.76) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL30343497 | 0.93 | MAOA (0.76) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL10849428 | 0.93 | MAOA (0.76) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL13043179 | 0.90 | CTSB (0.68) | MAPTMEN1KMT2AABCG2NPC1 | |
| SCHEMBL1938591 | 0.88 | MAPT (0.72) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL29377507 | 0.88 | MAPT (0.72) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL1938588 | 0.88 | MAPT (0.72) | MAPTTNFRSF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL19183205 | 0.87 | MAOB (0.76) | MAPTTNFRSF1AKMT2AALDH1A1ABCG2 | |
| SCHEMBL19183204 | 0.87 | MAOB (0.76) | MAPTTNFRSF1AKMT2AALDH1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112824370-A | Method for synthesizing pentamethoxyl chalcone | 南京科技职业学院 | 2021-05-21 | — | — | CN | claimed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | claimed |
| CN-112824370-A | Method for synthesizing pentamethoxyl chalcone | 南京科技职业学院 | 2021-05-21 | — | — | CN | disclosed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
| EP-1976818-A2 | CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | ABCE1, CCNE1, FOXM1 | MAPT 4453/4885TNFRSF1A 2869/4885MEN1 2708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.