SCHEMBL445084

SCHEMBL445084

O=C(c1ccccc1)C1CC=CCC1C(=O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.47
TDP1 Q9NUW8 2/20 0.47
MAPT P10636 2/20 0.45
ALOX15 P16050 1/20 0.45
HTT P42858 1/20 0.45
HBB P68871 1/20 0.45
GAA P10253 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CA2 P00918 1/20 0.44
CA4 P22748 1/20 0.44
MCL1 Q07820 1/20 0.44
TSHR P16473 4/20 0.44
CES1 P23141 3/20 0.44
CES2 O00748 2/20 0.44
DAO P14920 1/20 0.44
NAPRT Q6XQN6 1/20 0.44
ALDH1A1 P00352 1/20 0.44
EPHX1 P07099 1/20 0.44
HSD17B10 Q99714 2/20 0.43
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3315890 0.94 POLB (0.56) POLBTDP1MAPTHTTGAA
SCHEMBL7000719 0.84 AKR1C3 (0.45) POLBTDP1MAPTGAASMN1; SMN2
SCHEMBL22570568 0.81 MCL1 (0.52) POLBTDP1MAPTALOX15HTT
SCHEMBL7850490 0.81 KMO (0.48) POLBTDP1MAPTALOX15HTT
SCHEMBL7850492 0.81 KMO (0.48) POLBTDP1MAPTALOX15HTT
SCHEMBL3315896 0.79 POLB (0.36) POLBTDP1MAPTALOX15HTT
Benzoic Acid SCHEMBL6049039 0.78 TDP1 (0.62) POLBTDP1MAPTGAASMN1; SMN2
SCHEMBL9420049 0.78 CA1 (0.50) CA2CES1CES2MEN1KMT2A
SCHEMBL9920449 0.77 MCL1 (0.58) MAPTALOX15HTTHBBMCL1
SCHEMBL18668123 0.77 SMN1; SMN2 (0.51) POLBTDP1MAPTHTTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
EP-0921119-B1 Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2003-07-02 EP disclosed
US-6114360-A Pyrrole compounds ADIR ET COMPAGNIE (FR) 2000-09-05 US disclosed
US-6063804-A Pyrrole compounds ADIR ET COMPAGNIE (FR) 2000-05-16 US disclosed
EP-0921119-A1 Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1999-06-09 EP disclosed