Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514613 | 0.91 | ALDH1A1 (0.55) | ALDH1A1SLC6A4CYP2C9CYP2C19HPGD | |
| SCHEMBL328867 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL28227064 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SLC6A4CYP2C9CYP2C19HPGD | |
| SCHEMBL10863955 | 0.80 | ALDH1A1 (0.55) | ALDH1A1SLC6A4CYP2C9CYP2C19HPGD | |
| SCHEMBL4450988 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SLC6A4CYP2C9CYP2C19HPGD | |
| SCHEMBL31344396 | 0.74 | ROCK2 (0.52) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL22614679 | 0.74 | ROCK2 (0.52) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL4779691 | 0.74 | ROCK2 (0.52) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL447136 | 0.74 | CYP2C9 (0.48) | ALDH1A1SLC6A4CYP2C9CYP2C19HPGD | |
| SCHEMBL31344399 | 0.74 | ROCK2 (0.52) | ALDH1A1CYP2C9CYP2C19HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253932-A1 | Resolution of Racemic Organic Acids with (1S, 4S)-4[3,4-Dichlorophenyl]-1,2,3,4-Tetrahydro-N-Methyl-1-Naphthaloneamine | MATRIX LABORATORIES LTD (IN) | 2009-10-08 | — | — | US | disclosed |
| EP-1831132-A2 | RESOLUTION OF RACEMIC ORGANIC ACIDS WITH (1S, 4S)-4[3,4-DICHLOROPHENYL]-1,2,3,4- TETRAHYDRO-N-METHYL-1-NAPHTHALONEAMINE | Matrix Laboratories Ltd (IN) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006013581-A2 | RESOLUTION OF RACEMIC ORGANIC ACIDS WITH (1S, 4S)-4[3,4-DICHLOROPHENYL]-1,2,3,4- TETRAHYDRO-N-METHYL-1-NAPHTHALONEAMINE | MATRIX LABORATORIES LTD (IN) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253932-A1 | Resolution of Racemic Organic Acids with (1S, 4S)-4[3,4-Dichlorophenyl]-1,2,3,4-Tetrahydro-N-Methyl-1-Naphthaloneamine | HTR4, OXER1, CYP2S1 | ALDH1A1 464/4885SLC6A4 75/4885CYP2C9 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.