Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 6/20 | 0.55 |
| ▸ | DRD3 | P35462 | 6/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612087 | 0.95 | ALDH1A1 (0.62) | ALDH1A1KDM4ETDP1DRD2DRD3 | |
| SCHEMBL3611072 | 0.94 | DRD2 (0.58) | KDM4EDRD2DRD3DRD4HTR2A | |
| SCHEMBL3615992 | 0.87 | DRD2 (0.69) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4564398 | 0.80 | DRD2 (0.66) | ALDH1A1DRD2DRD3DRD4DRD1 | |
| SCHEMBL4445019 | 0.78 | DRD3 (0.60) | ALDH1A1DRD2DRD3DRD4DRD1 | |
| SCHEMBL3614806 | 0.77 | DRD2 (0.71) | ALDH1A1KDM4ETDP1DRD2DRD3 | |
| SCHEMBL3618645 | 0.77 | DRD2 (0.68) | ALDH1A1KDM4ETDP1DRD2DRD3 | |
| SCHEMBL3618095 | 0.76 | DRD2 (0.86) | KDM4EDRD2DRD3DRD4DRD1 | |
| SCHEMBL8724501 | 0.76 | ALDH1A1 (0.72) | ALDH1A1KDM4ETDP1DRD2DRD3 | |
| SCHEMBL8719445 | 0.76 | ALDH1A1 (0.72) | ALDH1A1KDM4ETDP1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137185-A2 | INDOLIZINES AND AZA-ANALOG DERIVATIVES THEREOF AS CNS ACTIVE COMPOUNDS | Gmeiner, Dr. Peter (DE) | 2009-12-30 | — | — | EP | claimed |
| WO-2008113559-A2 | INDOLIZINES AND AZA-ANALOG DERIVATIVES THEREOF AS CNS ACTIVE COMPOUNDS | SCHWARZ PHARMA AG (DE) | 2008-09-25 | — | — | WO | claimed |