Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 7/20 | 0.42 |
| ▸ | MMP9 | P14780 | 6/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13866546 | 0.82 | F10 (0.55) | — | |
| SCHEMBL3747259 | 0.81 | F10 (0.58) | — | |
| SCHEMBL7300170 | 0.77 | POLB (0.55) | ADAMTS4MMP13POLBALDH1A1MAPT | |
| SCHEMBL7300164 | 0.77 | POLB (0.55) | ADAMTS4MMP13POLBALDH1A1MAPT | |
| SCHEMBL7240211 | 0.75 | ALDH1A1 (0.56) | ADAMTS4MMP13TYMSPOLBALDH1A1 | |
| SCHEMBL7240207 | 0.75 | ALDH1A1 (0.56) | ADAMTS4MMP13TYMSPOLBALDH1A1 | |
| SCHEMBL25453255 | 0.74 | CYP2D6 (0.52) | POLBALDH1A1CYP2C19CYP1A2HTT | |
| SCHEMBL4557815 | 0.74 | ITGB3 (0.42) | ALDH1A1 | |
| SCHEMBL2780433 | 0.72 | CYP2D6 (0.49) | ALDH1A1CYP2C19HTTCYP2D6CYP2C9 | |
| SCHEMBL6193349 | 0.72 | CYP2D6 (0.49) | ALDH1A1CYP2C19HTTCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511721-B1 | GUANIDINO PHENYLALANIN COMPOUNDS USED AS UROKINASE INHIBITORS | WILEX AG (DE) | 2009-07-01 | — | — | EP | disclosed |
| US-7538216-B2 | Guanidino phenylalanin compounds used as urokinase inhibitors | WILEX AG (DE) | 2009-05-26 | — | — | US | disclosed |
| US-20050267127-A1 | Guanidino phenylalanin compounds used as urokinase inhibitors | WILEX AG (DE) | 2005-12-01 | — | — | US | disclosed |
| EP-1511721-A2 | GUANIDINO PHENYLALANIN COMPOUNDS USED AS UROKINASE INHIBITORS | Wilex AG (DE) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003103644-A2 | GUANIDINO PHENYLALANIN COMPOUNDS USED AS UROKINASE INHIBITORS | WILEX AG (DE) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267127-A1 | Guanidino phenylalanin compounds used as urokinase inhibitors | PLAU, PLAUR, ENPEP | ADAMTS4 297/4885MMP13 121/4885TYMS 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.