Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44135 | 0.90 | MEN1 (0.42) | AAK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL43813 | 0.86 | LMNA (0.54) | AAK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL44934 | 0.83 | AAK1 (0.46) | AAK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL43820 | 0.83 | PDE4D (0.43) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL44141 | 0.82 | LMNA (0.56) | MEN1KMT2AMAPTALDH1A1PIM2 | |
| SCHEMBL12926176 | 0.81 | LMNA (0.43) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL38941 | 0.78 | SMN1; SMN2 (0.47) | MEN1KMT2AALDH1A1MAPK1PKM | |
| SCHEMBL44718 | 0.78 | MAP4K2 (0.45) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL39292 | 0.76 | SMN1; SMN2 (0.56) | MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL38703 | 0.76 | WDR5 (0.44) | ALDH1A1KDM4ERAB9AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |