Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.45 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39065 | 0.89 | HTT (0.41) | MAP4K2MAPK1MAP4K4MAPTRAB9A | |
| SCHEMBL44141 | 0.81 | LMNA (0.56) | MAP4K2SYKMAPK1CDC7PLK4 | |
| SCHEMBL44514 | 0.78 | AAK1 (0.48) | MAP4K2MAPK1PIM2MAPTRAB9A | |
| SCHEMBL44454 | 0.77 | CHEK2 (0.36) | GSK3BMAPTLMNAHTTPOLB | |
| SCHEMBL44171 | 0.75 | ROCK1 (0.41) | ROCK2KITROCK1 | |
| SCHEMBL45017 | 0.75 | PIK3CA (0.35) | ROCK2ROCK1DYRK1AMAPTRAB9A | |
| SCHEMBL13844884 | 0.75 | WDR5 (0.41) | ROCK2GSK3AGSK3BROCK1CLK4 | |
| SCHEMBL44471 | 0.74 | ROCK1 (0.40) | ROCK2KITROCK1MAPTLMNA | |
| SCHEMBL43813 | 0.74 | LMNA (0.54) | SYKMAPK1MAPTRAB9ANPC1 | |
| SCHEMBL44007 | 0.73 | ALDH1A1 (0.41) | ROCK2KITFLT3ROCK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |