Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564723 | 0.76 | ALDH1A1 (0.36) | KDM4EMAPTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL28687392 | 0.72 | MAPT (0.49) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL10448991 | 0.72 | MAPT (0.49) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11499749 | 0.71 | NAAA (0.41) | ALDH1A1GPR84NAAAFFAR1EPHX1 | |
| SCHEMBL22433662 | 0.70 | GPR84 (0.48) | MAPTL3MBTL1MAPK1NPSR1GPR84 | |
| SCHEMBL11177014 | 0.70 | EPHX1 (0.50) | MAPTALDH1A1GPR84FFAR1EPHX1 | |
| SCHEMBL7597231 | 0.70 | EPHX1 (0.50) | MAPTALDH1A1GPR84FFAR1EPHX1 | |
| SCHEMBL10587077 | 0.70 | GPR84 (0.47) | MAPTGPR84NAAAFFAR1EPHX1 | |
| SCHEMBL11581198 | 0.69 | SMN1; SMN2 (0.62) | MAPTGPR84FFAR1EPHX1 | |
| SCHEMBL11581195 | 0.69 | SMN1; SMN2 (0.62) | MAPTGPR84FFAR1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544700-B2 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein JunKinases | LABORATOIRES SERONO SA (CH) | 2009-06-09 | — | — | US | disclosed |