Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST6GAL1 | P15907 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6367031 | 0.91 | ST6GAL1 (0.37) | ST6GAL1LMNATHRBMTORMDM2 | |
| SCHEMBL6361362 | 0.89 | L3MBTL1 (0.36) | ST6GAL1LMNATHRBMTORMDM2 | |
| SCHEMBL5341103 | 0.89 | ST6GAL1 (0.35) | ST6GAL1LMNATHRBMTORMDM2 | |
| SCHEMBL4452574 | 0.89 | LMNA (0.43) | ST6GAL1LMNATHRBMTORMDM2 | |
| SCHEMBL6363635 | 0.87 | ST6GAL1 (0.34) | ST6GAL1LMNATHRBMTORMDM2 | |
| SCHEMBL6850447 | 0.83 | ST6GAL1 (0.32) | ST6GAL1LMNATHRBMTORMDM2 | |
| SCHEMBL16243090 | 0.78 | ST6GAL1 (0.31) | ST6GAL1 | |
| SCHEMBL2217911 | 0.77 | LMNA (0.37) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL15476977 | 0.77 | LMNA (0.37) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL2113320 | 0.77 | LMNA (0.47) | ST6GAL1LMNATHRBMTORMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090198047-A1 | 2'-Modified Oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-20080032945-A1 | 2'-MODIFIED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | US | disclosed |
| US-7138517-B2 | Sugar modified oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2006-11-21 | — | — | US | disclosed |
| US-20030187240-A1 | 2' -modified oligonucleotides | ISIS PHARMACEUTICALS, INC. | 2003-10-02 | — | — | US | disclosed |
| US-20030004325-A1 | Sugar modified oligonucleotides | ISIS PHARMACEUTICALS, INC. | 2003-01-02 | — | — | US | disclosed |
| US-6399754-B1 | CONTAINING SULFOPHOSPHATE GROUP | ISIS PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |