SCHEMBL6850447

CCOC1(O[C@@H]2[C@@H]3O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC(C(=O)c4ccccc4)[C@H]3O[C@H]2n2ccc(N)nc2=O)C(=O)C2C(C1=O)C2(C)C

nearest known ligand 0.35

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	ST6GAL1	P15907	2/20	0.32

▸	LMNA	P02545	1/20	0.31

▸	THRB	P10828	1/20	0.31

▸	MTOR	P42345	1/20	0.31

▸	MDM2	Q00987	1/20	0.31

▸	NCOA1	Q15788	1/20	0.31

▸	NCOA3	Q9Y6Q9	1/20	0.31

▸	NT5E	P21589	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6367031	0.86	ST6GAL1 (0.37)	ST6GAL1LMNATHRBMTORMDM2
SCHEMBL4451630	0.83	ST6GAL1 (0.36)	ST6GAL1LMNATHRBMTORMDM2
SCHEMBL6363635	0.83	ST6GAL1 (0.34)	ST6GAL1LMNATHRBMTORMDM2
SCHEMBL6361362	0.82	L3MBTL1 (0.36)	ST6GAL1LMNATHRBMTORMDM2
SCHEMBL5341103	0.81	ST6GAL1 (0.35)	ST6GAL1LMNATHRBMTORMDM2
SCHEMBL4452574	0.79	LMNA (0.43)	ST6GAL1LMNATHRBMTORMDM2
SCHEMBL6362501	0.77	POLB (0.39)	NT5E
SCHEMBL15476977	0.72	LMNA (0.37)	LMNATHRBMTORMDM2NCOA1
SCHEMBL2217911	0.72	LMNA (0.37)	LMNATHRBMTORMDM2NCOA1
SCHEMBL16243090	0.71	ST6GAL1 (0.31)	ST6GAL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0942000-B1	2'-Modified oligonucleotides	ISIS PHARMACEUTICALS INC (US)	2004-06-23	—	—	EP	disclosed
EP-0942000-A2	2'Modified oligonucleotides	ISIS PHARMACEUTICALS, INC. (US)	1999-09-15	—	—	EP	disclosed