Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530311 | 0.82 | CES2 (0.32) | SCN10ADPP4CES2CES1 | |
| SCHEMBL172564 | 0.81 | GBA1 (0.34) | GBA1IDO1TDO2CES2CES1 | |
| SCHEMBL13995183 | 0.81 | GBA1 (0.36) | GBA1IDO1TDO2HTR2AHTR2C | |
| SCHEMBL22694855 | 0.80 | HRH1 (0.34) | GBA1IDO1TDO2DPP4CES2 | |
| SCHEMBL1729210 | 0.78 | CA2 (0.45) | GBA1 | |
| SCHEMBL1729000 | 0.78 | CA2 (0.45) | GBA1 | |
| SCHEMBL7939350 | 0.77 | CES2 (0.35) | GBA1IDO1TDO2CES2CES1 | |
| SCHEMBL1727640 | 0.76 | SLC6A4 (0.42) | GBA1IDO1TDO2CES2CES1 | |
| SCHEMBL1727838 | 0.76 | SLC6A4 (0.42) | GBA1IDO1TDO2CES2CES1 | |
| SCHEMBL12261531 | 0.76 | SLC6A4 (0.42) | GBA1IDO1TDO2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212277-B1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA NV (BE) | 2016-08-31 | — | — | EP | disclosed |
| EP-2212277-B1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA NV (BE) | 2016-08-31 | — | — | EP | disclosed |
| US-8247610-B2 | Amine linked modulators of γ-secretase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-08-21 | — | — | US | disclosed |
| US-8247610-B2 | Amine linked modulators of γ-secretase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-08-21 | — | — | US | disclosed |
| US-8247610-B2 | Amine linked modulators of γ-secretase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-08-21 | — | — | US | disclosed |
| US-20090306392-A1 | GSM INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-10 | — | — | US | disclosed |
| US-20090306392-A1 | GSM INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-10 | — | — | US | disclosed |
| US-20090306392-A1 | GSM INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-10 | — | — | US | disclosed |
| WO-2009052341-A1 | GSM INTERMEDIATES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |
| US-20090105300-A1 | AMINE LINKED MODULATORS OF y-SECRETASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105300-A1 | AMINE LINKED MODULATORS OF y-SECRETASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105300-A1 | AMINE LINKED MODULATORS OF y-SECRETASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-23 | — | — | US | disclosed |
| WO-2009052350-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306392-A1 | GSM INTERMEDIATES | BACE1, GSAP, PSEN1 | GBA1 20/4885SCN10A 1801/4885IDO1 4428/4885 |
| US-20090105300-A1 | AMINE LINKED MODULATORS OF y-SECRETASE | BACE1, BACE2, APP | GBA1 90/4885SCN10A 1661/4885IDO1 1711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.