SCHEMBL445250

SCHEMBL445250

C=CCOc1cccc(N)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.58
TP53 P04637 1/20 0.58
MAOB P27338 2/20 0.53
TSHR P16473 1/20 0.50
APP P05067 1/20 0.49
ALDH1A1 P00352 1/20 0.48
MAPT P10636 2/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CA12 O43570 3/20 0.43
CA1 P00915 3/20 0.43
CA9 Q16790 3/20 0.43
CA2 P00918 1/20 0.43
CA7 P43166 1/20 0.43
ADRA2A P08913 1/20 0.42
ADRA2B P18089 1/20 0.42
ADRA2C P18825 1/20 0.42
KDM4E B2RXH2 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4729728 0.98 CYP3A4 (0.56) CYP3A4TP53MAOBTSHRAPP
SCHEMBL1520719 0.86 MEN1 (0.50) CYP3A4ALDH1A1MAPTMEN1LMNA
SCHEMBL26086854 0.81 TSHR (0.56) CYP3A4TP53MAOBTSHRAPP
SCHEMBL20554872 0.81 MAOA (0.48) CYP3A4TP53MAOBALDH1A1MAPT
SCHEMBL513678 0.81 CYP3A4 (0.58) CYP3A4TP53MAOBTSHRAPP
SCHEMBL30375456 0.80 TSHR (0.58) CYP3A4TP53MAOBTSHRAPP
SCHEMBL22215904 0.80 MEN1 (0.47) ALDH1A1MAPTMEN1LMNAKMT2A
SCHEMBL22085949 0.80 MEN1 (0.46) MAPTMEN1LMNAKMT2ASMN1; SMN2
SCHEMBL8116474 0.80 ALDH1A1 (0.50) CYP3A4TP53MAOBTSHRAPP
SCHEMBL27521688 0.79 CA12 (0.44) TP53ALDH1A1MAPTMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119472194-A Phenol-free positive photoresist stripping liquid and preparation method thereof 浙江尚能实业股份有限公司 2025-02-18 CN claimed
CN-113151919-B Fiber and disc for biological rotating disc and preparation method 马东兵 2022-08-23 CN claimed
CN-113151919-A Fiber and disc for biological rotating disc and preparation method 马东兵 2021-07-23 CN claimed
WO-2025096608-A1 EGFR COVALENT INHIBITION WITH MACROCYCLES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2025-05-08 WO disclosed
CN-119472194-A Phenol-free positive photoresist stripping liquid and preparation method thereof 浙江尚能实业股份有限公司 2025-02-18 CN disclosed
CN-114436978-B Antifungal compound and application thereof 中国人民解放军海军军医大学 2024-06-18 CN disclosed
CN-114940692-B Compound with anti-lung cancer effect and preparation method and application thereof 重庆文理学院 2023-12-01 CN disclosed
US-20230381321-A1 CAMPTOTHECIN CONJUGATES SEAGEN INC. 2023-11-30 US disclosed
US-20230381321-A1 CAMPTOTHECIN CONJUGATES SEAGEN INC. 2023-11-30 US disclosed
WO-2023178289-A2 CAMPTOTHECIN CONJUGATES SEAGEN INC. (US) 2023-09-21 WO disclosed
US-20220387602-A1 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE NOVARTIS AG (CH) 2022-12-08 US disclosed
EP-0287479-A1 Thermally stable polymers based on maleimides and diamine siloxanes, and process for their preparation RHONE-POULENC CHIMIE (FR) 1988-10-19 EP disclosed
US-4777237-A HEAT-RESISTANT THERMOSETTING MOLDING MATERIALS RHONE-POULENC SPECIALITIES CHIMIQUES (FR) 1988-10-11 US disclosed
EP-0284520-A1 Thermally stable polymers based on maleimides, among which a bis-maleimide-siloxane, and processes for their preparation RHONE-POULENC CHIMIE (FR) 1988-09-28 EP disclosed
EP-0284524-A1 Thermostable polymers based on maleimides, of which one is a bismaleimide-siloxane, and on aromatic diamines, and process for their preparation RHONE-POULENC CHIMIE (FR) 1988-09-28 EP disclosed
EP-0284519-A1 Bismaleimide siloxanes and process for their preparation CIBA-GEIGY AG (CH) 1988-09-28 EP disclosed
EP-0274271-A1 Fungicidal carbanilates, process for the production thereof, compositions containing them and method of use thereof STAUFFER AGRICULTURAL CHEMICALS COMPANY, INC. (US) 1988-07-13 EP disclosed
US-4742141-A HEAT-STABLE; IMPREGNANTS; COATING OR MOLDING RESINS RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1988-05-03 US disclosed
EP-0208634-A1 Maleimides and thermohardening compositions containing them RHONE-POULENC CHIMIE (FR) 1987-01-14 EP disclosed
US-4027037-A ARTHROPOD METAMORPHOSIS INHIBITORS BAYER AKTIENGESELLSCHAFT (DT) 1977-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387602-A1 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE JMJD7, MDM2, IDE CYP3A4 2539/4885TP53 126/4885MAOB 883/4885
US-20230381321-A1 CAMPTOTHECIN CONJUGATES DCLRE1A, TOP2A, PAICS CYP3A4 3280/4885TP53 181/4885MAOB 3675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.