SCHEMBL4452595

SCHEMBL4452595

O=C(Cl)C(=CC=Cc1ccccc1)C(=O)Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.50
MCL1 Q07820 1/20 0.49
LMNA P02545 6/20 0.48
ALDH1A1 P00352 3/20 0.48
TRPA1 O75762 1/20 0.48
ALOX5 P09917 1/20 0.48
MAPK1 P28482 1/20 0.48
HDAC3 O15379 3/20 0.47
HDAC4 P56524 3/20 0.47
HDAC1 Q13547 3/20 0.47
HDAC2 Q92769 3/20 0.47
HDAC8 Q9BY41 3/20 0.47
HDAC6 Q9UBN7 3/20 0.47
HDAC7 Q8WUI4 2/20 0.47
HDAC10 Q969S8 2/20 0.47
HDAC11 Q96DB2 2/20 0.47
HDAC9 Q9UKV0 2/20 0.47
HDAC5 Q9UQL6 2/20 0.47
MAPT P10636 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4452592 1.00 MAOB (0.50) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL7728995 0.84 GRIK1 (0.39) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL8103328 0.84 TDP1 (0.40) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL27635900 0.84 MAOB (0.50) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL1614744 0.83 MAOB (0.54) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL1614745 0.83 MAOB (0.54) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL8103329 0.83 PPARA (0.40) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL7728991 0.83 GRIK1 (0.41) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL8862864 0.82 GRIK1 (0.44) MAOBMCL1LMNAALDH1A1TRPA1
SCHEMBL8103325 0.81 GRIK1 (0.39) MCL1LMNAALDH1A1MAPK1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101405303-B Acrylated hyaluronic acid NOVOZYMES BIOPHARMA DK AS 2011-11-23 CN disclosed
EP-1999160-B1 ACRYLATED HYALURONIC ACID NOVOZYMES BIOPHARMA DK AS (DK) 2009-12-30 EP disclosed
US-20090118423-A1 Acrylated Hyaluronic Acid NOVOZYMES BIOPOLYMER A/S (DK) 2009-05-07 US disclosed
CN-101405303-A Acrylated hyaluronic acid NOVOZYMES BIOPOLYMER AS (DK) 2009-04-08 CN disclosed
EP-1999160-A2 ACRYLATED HYALURONIC ACID Novozymes Biopolymer A/S (DK) 2008-12-10 EP disclosed
US-7378203-B2 Ferrocene(di)carboxaldehyde N-phenylhydrazone and monomeric, bridged or polymeric derivatives; good mechanical and electrostatic properties; can be used with liquid and dry toners to produce high quality images; imaging systems can be maintained after repeated cycling; electrography SAMSUNG ELECTRONICS CO., LTD. (KR) 2008-05-27 US disclosed
WO-2007106738-A2 ACRYLATED HYALURONIC ACID NOVOZYMES BIOPOLYMER A/S (DK) 2007-09-20 WO disclosed
US-20060210897-A1 Charge transport materials having at least a metallocene group S-PRINTING SOLUTION CO., LTD. (KR) 2006-09-21 US disclosed
US-5942387-A Combinatorial process for preparing substituted thiophene libraries ELI LILLY AND COMPANY (US) 1999-08-24 US disclosed
EP-0825164-A2 Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides ELI LILLY AND COMPANY (US) 1998-02-25 EP disclosed
US-4284705-A EXPOSURE, DEVELOPMENT, COATING EASTMAN KODAK COMPANY (US) 1981-08-18 US disclosed
US-4215041-A Diazo substituted amino-benzene salts and lithographic plate comprising same EASTMAN KODAK COMPANY (US) 1980-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118423-A1 Acrylated Hyaluronic Acid CD44, ACR, MUC1 MAOB 1865/4885MCL1 3121/4885LMNA 2588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.