⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30511 | 1.00 | — | — | |
| SCHEMBL9279532 | 1.00 | — | — | |
| SCHEMBL1254524 | 1.00 | — | — | |
| SCHEMBL4450273 | 1.00 | — | — | |
| SCHEMBL245244 | 1.00 | — | — | |
| SCHEMBL17681496 | 1.00 | — | — | |
| SCHEMBL9047529 | 1.00 | — | — | |
| SCHEMBL24870211 | 0.97 | MBTD1 (0.39) | — | |
| SCHEMBL2378409 | 0.97 | MBTD1 (0.39) | — | |
| Lithium SCHEMBL29834968 | 0.97 | MBTD1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023661-A1 | Use of Antagonists of the Bradykinin B2 Receptor for the Treatment of Osteoarthrosis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2009-01-22 | — | — | US | claimed |
| US-20040248809-A1 | Use of antagonists of the bradykinin B2 receptor for the treatment of osteoarthrosis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-12-09 | — | — | US | claimed |
| US-5648333-A | POLYPEPTIDES FOR ANTIINFLAMMATORY AGENTS, WOUND HEALING AGENTS, ANTIALLERGENS OR CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-15 | — | — | US | claimed |
| EP-0476457-B1 | 2-Benzothiazolyl tetrazolium salt indicators | BAYER AG (US) | 1996-12-04 | — | — | EP | claimed |
| EP-0370453-B1 | Peptides having a Brady kinine-inhibiting activity | HOECHST AG (DE) | 1994-06-15 | — | — | EP | claimed |
| EP-0370453-A2 | Peptides having a Brady kinine-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| EP-0214570-A2 | N-alkylated tripeptides, process for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-18 | — | — | EP | claimed |
| JP-5017474-A | — | — | None | — | — | JP | disclosed |
| EP-4429465-A1 | COMPOSITIONS COMPRISING TRPM8 AGONISTIC COOLING AGENTS | Symrise AG (DE) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023083445-A1 | COMPOSITIONS COMPRISING TRPM8 AGONISTIC COOLING AGENTS | SYMRISE AG (DE) | 2023-05-19 | — | — | WO | disclosed |
| EP-2576803-B1 | PREPARATION OF (3aS,7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYZED BIOLOGICAL RESOLUTION OF DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE | BGP PRODUCTS OPERATIONS GMBH (CH) | 2019-07-10 | — | — | EP | disclosed |
| US-10197557-B2 | Small molecules for endothelial cell activation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-02-05 | — | — | US | disclosed |
| US-9080193-B2 | Preparation of (3aS,7aR)-hexahydroisobenzofuran-1(3H)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate | ABBVIE INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-5202335-A | Hypoglycemic, antidiabetic agents | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| JP-H0517474-A | PRODUCTION OF HYDROXYIMINOOCTAHYDROINDOLE (2,3-A) QUINOLIDINE DERIVATIVE | RICHTER GEDEON V G RT | 1993-01-26 | — | — | JP | disclosed |
| EP-0507534-A1 | Succinic acid compounds | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1992-10-07 | — | — | EP | disclosed |
| EP-0370453-A2 | Peptides having a Brady kinine-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| US-4691022-A | Process for the preparation of monocyclic, bicyclic and tricyclic aminoacids | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-01 | — | — | US | disclosed |
| EP-0214570-A2 | N-alkylated tripeptides, process for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-18 | — | — | EP | disclosed |
| EP-0132580-A1 | Process for the preparation of mono, bi and tricyclic aminoacids | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-02-13 | — | — | EP | disclosed |