Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465211 | 0.89 | HRH3 (0.48) | HRH3OPRM1OPRK1PRMT5WDR77 | |
| SCHEMBL15251306 | 0.87 | HRH3 (0.57) | HRH3OPRM1OPRK1PRMT5WDR77 | |
| SCHEMBL25701780 | 0.83 | HIF1A (0.47) | HRH3PRMT5WDR77MEN1KMT2A | |
| SCHEMBL27815604 | 0.83 | HRH3 (0.61) | HRH3OPRM1OPRK1PRMT5WDR77 | |
| SCHEMBL15251315 | 0.83 | KDM5C (0.52) | HRH3OPRM1OPRK1PRMT5WDR77 | |
| SCHEMBL2828056 | 0.80 | OPRM1 (0.60) | HRH3OPRM1OPRK1KMT2APARP1 | |
| SCHEMBL4465984 | 0.79 | OPRM1 (0.41) | HRH3OPRM1OPRK1PRMT5WDR77 | |
| SCHEMBL30647277 | 0.78 | ADORA2A (0.52) | OPRM1OPRK1KMT2AKDM4EMAPT | |
| SCHEMBL2776747 | 0.77 | ALDH1A1 (0.59) | HRH3SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1126270 | 0.77 | GAA (0.49) | HRH3SMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |