Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | PAICS | P22234 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452722 | 0.89 | HRH3 (0.48) | HRH3PRMT5WDR77OPRM1OPRK1 | |
| SCHEMBL15251306 | 0.87 | HRH3 (0.57) | HRH3PRMT5WDR77HDAC6OPRM1 | |
| SCHEMBL9202121 | 0.83 | CHKA (0.55) | HRH3HDAC6PAICSKDM4EALDH1A1 | |
| SCHEMBL15251315 | 0.83 | KDM5C (0.52) | HRH3PRMT5WDR77OPRM1OPRK1 | |
| SCHEMBL27815604 | 0.83 | HRH3 (0.61) | HRH3PRMT5WDR77OPRM1OPRK1 | |
| SCHEMBL4465984 | 0.82 | OPRM1 (0.41) | HRH3MAP3K11PRMT5WDR77OPRM1 | |
| SCHEMBL5133060 | 0.79 | HRH3 (0.48) | HRH3MAP3K11HDAC6PAICSKDM4E | |
| SCHEMBL9377535 | 0.79 | HDAC6 (0.51) | HRH3HDAC6ALDH1A1SMN1; SMN2MAPK7 | |
| SCHEMBL4454098 | 0.79 | NNMT (0.40) | HRH3MAP3K11PRMT5WDR77OPRM1 | |
| SCHEMBL16621368 | 0.78 | OPRM1 (0.46) | HRH3MAP3K11HDAC6OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |