Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PDE4A | P27815 | 2/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | PDE6D | O43924 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | PDE9A | O76083 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PDE6A | P16499 | 1/20 | 0.56 |
| ▸ | PDE6G | P18545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zaprinast SCHEMBL50329 | 0.82 | PDE5A (0.56) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| Zaprinast SCHEMBL30276335 | 0.82 | PDE5A (0.56) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL1962446 | 0.81 | PDE5A (1.00) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL1962489 | 0.79 | PDE5A (0.68) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL7076702 | 0.78 | PDE5A (0.62) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL29230010 | 0.77 | PDE5A (0.56) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL7722659 | 0.76 | PDE5A (0.67) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL7402899 | 0.74 | PDE5A (0.56) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL10737563 | 0.74 | PDE5A (0.70) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL2604748 | 0.73 | PDE5A (0.92) | PDE5AKDM4EALDH1A1KMT2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507707-B2 | Methods of inducing ovulation using a non-polypeptide camp level modulator | LABORATOIRES SERONO SA (CH) | 2009-03-24 | — | — | US | claimed |
| US-7507707-B2 | Methods of inducing ovulation using a non-polypeptide camp level modulator | LABORATOIRES SERONO SA (CH) | 2009-03-24 | — | — | US | disclosed |
| CN-1473047-A | Method for treating hypogonadism | ������ҩ������˾ | 2004-02-04 | — | — | CN | disclosed |