Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.62 |
| ▸ | PDE4A | P27815 | 3/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | PDE6D | O43924 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | PDE9A | O76083 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701453 | 0.81 | PDE5A (0.69) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Zaprinast SCHEMBL30276335 | 0.79 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Zaprinast SCHEMBL50329 | 0.79 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4452818 | 0.78 | PDE5A (0.68) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7965712 | 0.77 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29230010 | 0.76 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10740756 | 0.74 | PDE5A (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7402899 | 0.73 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635857 | 0.72 | PDE5A (0.71) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7722659 | 0.72 | PDE5A (0.67) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030070674-A1 | Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine | PULMONOX TECHNOLOGIES CORPORATION (CA) | 2003-04-17 | — | — | US | claimed |
| US-20030070674-A1 | Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine | PULMONOX TECHNOLOGIES CORPORATION (CA) | 2003-04-17 | — | — | US | disclosed |