Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | CA3 | P07451 | 2/20 | 0.40 |
| ▸ | CA6 | P23280 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63328 | 0.91 | CYP2D6 (0.42) | TSHRAPEX1KDM4ELCKFYN | |
| SCHEMBL8899334 | 0.89 | ALDH1A1 (0.43) | TSHRAPEX1KDM4ELCKFYN | |
| Isophthalic Acid SCHEMBL9766398 | 0.88 | CA1 (0.42) | KDM4ELCKFYNCYP2D6CA1 | |
| 1,3-Propanediol SCHEMBL27591480 | 0.81 | CYP2D6 (0.36) | KDM4ELCKFYNCYP2D6CA2 | |
| 1,3-Propanediol SCHEMBL27591428 | 0.81 | CYP2D6 (0.36) | KDM4ELCKFYNCYP2D6CA2 | |
| SCHEMBL27723018 | 0.81 | CYP2D6 (0.36) | KDM4ELCKFYNCYP2D6ALDH1A1 | |
| SCHEMBL8899330 | 0.81 | ALDH1A1 (0.38) | KDM4ELCKFYNCYP2D6ALDH1A1 | |
| SCHEMBL29162781 | 0.81 | LCK (0.56) | TSHRTP53APEX1KDM4ELCK | |
| Terephthalic Acid SCHEMBL17685563 | 0.79 | ALOX15 (0.52) | TSHRTP53APEX1KDM4ELCK | |
| Terephthalic Acid SCHEMBL7867064 | 0.78 | ALOX15 (0.50) | TSHRTP53APEX1KDM4ELCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101001750-A | Container comprising a multilayer structure comprising polyester | DU PONT (US) | 2007-07-18 | — | — | CN | claimed |
| US-9708503-B2 | Resin-polyester blend binder compositions, method of making same and articles made therefrom | HEXION INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150247056-A1 | RESIN-POLYESTER BLEND BINDER COMPOSITIONS, METHOD OF MAKING SAME AND ARTICLES MADE THEREFROM | JPMORGAN CHASE BANK, N.A. | 2015-09-03 | — | — | US | disclosed |
| US-9062202-B2 | Resin-polyester blend binder compositions, method of making same and articles made therefrom | HEXION INC. (US) | 2015-06-23 | — | — | US | disclosed |
| EP-2115028-B1 | RESIN-POLYESTER BLEND BINDER COMPOSITIONS, METHOD OF MAKING SAME AND ARTICLES MADE THEREFROM | HEXION SPECIALTY CHEMICALS RES (BE) | 2015-01-28 | — | — | EP | disclosed |
| EP-2115028-A1 | RESIN-POLYESTER BLEND BINDER COMPOSITIONS, METHOD OF MAKING SAME AND ARTICLES MADE THEREFROM | Hexion Specialty Chemicals, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008106124-A1 | RESIN-POLYESTER BLEND BINDER COMPOSITIONS, METHOD OF MAKING SAME AND ARTICLES MADE THEREFROM | HEXION SPECIALTY CHEMICALS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |
| US-20080207833-A1 | RESIN-POLYESTER BLEND BINDER COMPOSITIONS, METHOD OF MAKING SAME AND ARTICLES MADE THEREFROM | JPMORGAN CHASE BANK, N.A. | 2008-08-28 | — | — | US | disclosed |
| CN-101001750-A | Container comprising a multilayer structure comprising polyester | DU PONT (US) | 2007-07-18 | — | — | CN | disclosed |
| US-20060009548-A1 | Formaldehyde-free binder compositions for simultaneous warp sizing and coloration of filament yarns | WILMINGTON TRUST COMPANY, AS COLLATERAL AGENT | 2006-01-12 | — | — | US | disclosed |
| US-6984675-B2 | Formaldehyde-free binder compositions for simultaneous warp sizing and coloration of filament yarns | RESOLUTION SPECIALTY MATERIALS LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20030105210-A1 | Formaldehyde-free binder compositions for simultaneous warp sizing and coloration of filament yarns | HEXION INC. (FORMERLY KNOWN AS MOMENTIVE SPECIALTY CHEMICALS INC.) | 2003-06-05 | — | — | US | disclosed |