SCHEMBL4453443

SCHEMBL4453443

Cc1ccc(C#Cc2ccc(C=O)cc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.73
CA12 O43570 3/20 0.48
CA2 P00918 3/20 0.48
CA9 Q16790 3/20 0.48
CA1 P00915 2/20 0.48
GRM5 P41594 2/20 0.47
KCNH2 Q12809 1/20 0.44
FFAR1 O14842 2/20 0.43
ALDH1A1 P00352 3/20 0.41
TYR P14679 1/20 0.41
CYP2A13 Q16696 1/20 0.41
HSD17B10 Q99714 1/20 0.41
ALDH5A1 P51649 1/20 0.41
ABAT P80404 1/20 0.41
KDM4E B2RXH2 1/20 0.41
VCP P55072 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13322003 0.89 CYP2A6 (0.57) CYP2A6CA12CA2CA9CA1
SCHEMBL8384841 0.88 CYP2A6 (0.50) CYP2A6FFAR1ALDH1A1TYRCYP2A13
SCHEMBL30635304 0.88 CYP2A6 (0.50) CYP2A6FFAR1ALDH1A1TYRCYP2A13
SCHEMBL30635286 0.88 CYP2A6 (0.50) CYP2A6FFAR1ALDH1A1TYRCYP2A13
SCHEMBL29171 0.85
SCHEMBL8469408 0.85 CYP2A6 (1.00) CYP2A6ALDH1A1TYRCYP2A13HSD17B10
P-Xylene SCHEMBL10939332 0.85 CYP2A6 (1.00) CYP2A6ALDH1A1TYRCYP2A13HSD17B10
SCHEMBL13247293 0.83 CYP2A6 (0.50) CYP2A6CA12CA2CA9CA1
SCHEMBL586330 0.83 CYP2A6 (0.94) CYP2A6ALDH1A1TYRCYP2A13HSD17B10
SCHEMBL586152 0.83 CYP2A6 (0.94) CYP2A6ALDH1A1TYRCYP2A13HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108358767-B Pentabenzyl benzene-containing difluoride monomer, preparation method and application thereof in polyaryletherketone functional film 吉林大学 2021-06-04 CN claimed
US-7479575-B2 Method for preparing para-phenyl alkynyl benzaldehydes LABORATOIRES SERONO SA (CH) 2009-01-20 US claimed
US-20080108849-A1 Method For Preparing Para-Phenyl Alkynyl Benzaldehydes APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2008-05-08 US claimed
EP-1675813-B1 METHOD FOR PREPARING PARA-PHENYL ALKYNYL BENZALDEHYDES SERONO LAB (CH) 2007-12-19 EP claimed
CN-108358767-B Pentabenzyl benzene-containing difluoride monomer, preparation method and application thereof in polyaryletherketone functional film 吉林大学 2021-06-04 CN disclosed
WO-2018115421-A1 COMPOUNDS USEFUL FOR TREATING A MANNHEIMIA HAEMOLYTICA OR HISTOPHILUS SOMNI INFECTION INTERVET INTERNATIONAL B.V. (NL) 2018-06-28 WO disclosed
WO-2018115432-A2 COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE INTERVET INTERNATIONAL B.V. (NL) 2018-06-28 WO disclosed
US-7479575-B2 Method for preparing para-phenyl alkynyl benzaldehydes LABORATOIRES SERONO SA (CH) 2009-01-20 US disclosed
US-7479575-B2 Method for preparing para-phenyl alkynyl benzaldehydes LABORATOIRES SERONO SA (CH) 2009-01-20 US disclosed
US-20080108849-A1 Method For Preparing Para-Phenyl Alkynyl Benzaldehydes APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2008-05-08 US disclosed
US-20080108849-A1 Method For Preparing Para-Phenyl Alkynyl Benzaldehydes APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2008-05-08 US disclosed
EP-1675813-B1 METHOD FOR PREPARING PARA-PHENYL ALKYNYL BENZALDEHYDES SERONO LAB (CH) 2007-12-19 EP disclosed
EP-1675813-A1 METHOD FOR PREPARING PARA-PHENYL ALKYNYL BENZALDEHYDES Applied Research Systems ARS Holding N.V. (NL) 2006-07-05 EP disclosed
WO-2005037758-A1 METHOD FOR PREPARING PARA-PHENYL ALKYNYL BENZALDEHYDES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) 2005-04-28 WO disclosed
CN-1056132-C Novel liquid crystal compounds having a dialkenyl moiety and liquid crystal compositions thereof CHISSO CORP (JP) 2000-09-06 CN disclosed
EP-0805134-B1 NOVEL LIQUID-CRYSTAL COMPOUNDS BEARING DIENYL MOIETY AND LIQUID-CRYSTAL COMPOSITION CHISSO CORP (JP) 2000-08-30 EP disclosed
US-6086964-A Liquid crystalline compound having dienyl moiety and liquid crystal composition CHISSO CORPORATION (JP) 2000-07-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080108849-A1 Method For Preparing Para-Phenyl Alkynyl Benzaldehydes TNNC1, CPT1B, MUSK CYP2A6 578/4885CA12 2857/4885CA2 657/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.