Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108698 | 0.72 | RAB9A (0.38) | KMT2AMEN1POLBRAB9ATGFBR1 | |
| SCHEMBL5349589 | 0.72 | MYC (0.49) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL16062228 | 0.64 | PDPK1 (0.43) | KDM4EKMT2AMAPTMEN1POLB | |
| SCHEMBL577445 | 0.63 | RAB9A (0.49) | KMT2AMEN1RAB9ATGFBR1PDPK1 | |
| SCHEMBL27676701 | 0.62 | MYC (0.42) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL28464800 | 0.62 | CYP19A1 (0.40) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL28636603 | 0.62 | MYC (0.44) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL3417300 | 0.61 | RAB9A (0.50) | ALDH1A1KMT2AMAPTMEN1RAB9A | |
| SCHEMBL28866322 | 0.60 | ALDH1A1 (0.48) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL26259375 | 0.60 | PDPK1 (0.59) | ALDH1A1KDM4EMAPTRAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504400-B2 | for the treatment of atherosclerosis, pancreatitis, obesity, hyper-triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes; apolipoprotein B secretion inhibitors also for lipid lowering activity; compounds can selectively block MTP at the level of the gut wall in mammals | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | claimed |
| EP-0361341-A2 | Therapeutics for aids based on inhibitors of HIV protease | MILES INC. (US) | 1990-04-04 | — | — | EP | claimed |
| EP-0361341-A2 | Therapeutics for aids based on inhibitors of HIV protease | MILES INC. (US) | 1990-04-04 | — | — | EP | disclosed |