Propionic Acid

Propionic Acid

SCHEMBL4453882

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nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 3/20 0.59
ALDH1A1 P00352 4/20 0.42
TDP1 Q9NUW8 4/20 0.42
LCK P06239 1/20 0.41
FYN P06241 1/20 0.41
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
POLB P06746 1/20 0.36
CA5A P35218 1/20 0.35
CA5B Q9Y2D0 1/20 0.35
TSHR P16473 4/20 0.35
LMNA P02545 1/20 0.35
SLC15A2 Q16348 1/20 0.35
APEX1 P27695 1/20 0.33
AKR1B1 P15121 1/20 0.32
HSD11B1 P28845 1/20 0.31
PPARG P37231 4/20 0.31
PPARD Q03181 4/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionic Acid SCHEMBL1237252 0.97 FFAR3 (0.62) FFAR3ALDH1A1TDP1LCKFYN
Propionic Acid SCHEMBL28174768 0.91 FFAR3 (0.71) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL2777824 0.91 FFAR3 (0.71) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL4664260 0.88 FFAR3 (0.59) FFAR3ALDH1A1TDP1LCKFYN
Propionic Acid SCHEMBL28589623 0.88 FFAR3 (0.67) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL28210432 0.88 FFAR3 (0.67) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL28304974 0.88 FFAR3 (0.67) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL28304976 0.88 FFAR3 (0.67) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL28071315 0.85 FFAR3 (0.62) FFAR3ALDH1A1TDP1HDAC3HDAC1
Propionic Acid SCHEMBL6734624 0.85 FFAR3 (0.62) FFAR3ALDH1A1TDP1HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940948-A4 WATER-ABSORBENT AGENT COMPOSITION AND METHOD FOR MANUFACTURING SAME NIPPON CATALYTIC CHEM IND (JP) 2009-05-27 EP disclosed
EP-1940948-A1 WATER-ABSORBENT AGENT COMPOSITION AND METHOD FOR MANUFACTURING SAME Nippon Shokubai Co., Ltd. (JP) 2008-07-09 EP disclosed
WO-2007037522-A1 WATER-ABSORBENT AGENT COMPOSITION AND METHOD FOR MANUFACTURING SAME NIPPON SHOKUBAI CO., LTD. (JP) 2007-04-05 WO disclosed