Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL5073547 | 0.94 | FFAR3 (0.67) | FFAR3TDP1ALDH1A1LDHASRR | |
| Propionic Acid SCHEMBL6734624 | 0.91 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1LDHASRR | |
| Propionic Acid SCHEMBL1237252 | 0.91 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1LCKFYN | |
| Propionic Acid SCHEMBL4453882 | 0.88 | FFAR3 (0.59) | FFAR3TDP1ALDH1A1LCKFYN | |
| Propionic Acid SCHEMBL28107860 | 0.88 | FFAR3 (0.59) | FFAR3TDP1ALDH1A1LDHASRR | |
| Propionic Acid SCHEMBL2167213 | 0.86 | FFAR3 (0.56) | FFAR3TDP1ALDH1A1LDHASRR | |
| Propionic Acid SCHEMBL28174768 | 0.84 | FFAR3 (0.71) | FFAR3TDP1ALDH1A1LDHASRR | |
| Propionic Acid SCHEMBL2777824 | 0.84 | FFAR3 (0.71) | FFAR3TDP1ALDH1A1LDHASRR | |
| Propionic Acid SCHEMBL386699 | 0.84 | FFAR3 (0.83) | FFAR3TDP1ALDH1A1LCKFYN | |
| Acetic Acid SCHEMBL6288674 | 0.84 | FFAR3 (0.58) | FFAR3TDP1ALDH1A1LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889881-A2 | A method for producing an azo compound | Fujifilm Corporation (JP) | 2008-02-20 | — | — | EP | disclosed |
| US-5510235-A | LOW TEMPERATURE STORAGE STABILITY, RESISTANCE TO REDUCTION IN SEASONED BLEACHES | EASTMAN KODAK COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0636936-A1 | Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction | EASTMAN KODAK COMPANY (US) | 1995-02-01 | — | — | EP | disclosed |