Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228245 | 0.83 | ALOX12 (0.53) | ALOX15ALOX12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL9187057 | 0.76 | DRD1 (0.48) | ALOX15ALOX12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL226782 | 0.74 | DRD2 (0.40) | ALOX15ALOX12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL224561 | 0.71 | ALOX12 (0.47) | ALOX15ALOX12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4361668 | 0.69 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EMAOBKDM1A | |
| SCHEMBL4429729 | 0.69 | MAP2K3 (0.56) | ALOX15ALOX12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL11959229 | 0.69 | ALDH1A1 (0.51) | ALOX15ALOX12ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL428339 | 0.69 | ALDH1A1 (0.60) | ALDH1A1KMT2ASMN1; SMN2MAPK1MEN1 | |
| SCHEMBL12769106 | 0.68 | DRD2 (0.45) | ALDH1A1MAOBKDM1AMAOA | |
| SCHEMBL10815794 | 0.68 | CYP19A1 (0.66) | ALDH1A1KMT2ASMN1; SMN2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074102-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008043567-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2008-04-17 | — | — | WO | disclosed |