SCHEMBL4454044

SCHEMBL4454044

O=C(NO)c1cccc(C(=O)NO)n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 5/20 0.59
POLB P06746 1/20 0.57
KDM4E B2RXH2 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
ALOX15 P16050 2/20 0.54
TSHR P16473 1/20 0.54
ACMSD Q8TDX5 1/20 0.54
PTGS1 P23219 2/20 0.50
PTGS2 P35354 2/20 0.50
LMNA P02545 2/20 0.48
P2RX7 Q99572 1/20 0.48
HDAC1 Q13547 3/20 0.47
HDAC6 Q9UBN7 3/20 0.47
GAA P10253 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPC1 O15118 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5866071 0.98 HDAC8 (0.57) HDAC8POLBKDM4ETDP1ALOX15
SCHEMBL29687188 0.89 HDAC8 (0.50) HDAC8POLBKDM4ETDP1ALOX15
SCHEMBL2404959 0.87 ALDH1A1 (0.60) HDAC8POLBKDM4ETDP1ALOX15
SCHEMBL27362579 0.85 P2RX7 (0.70) HDAC8POLBP2RX7HDAC6NPC1
SCHEMBL8925424 0.84 HDAC8 (0.46) HDAC8POLBKDM4ETDP1ALOX15
SCHEMBL22281464 0.82 TERT (0.53) HDAC8POLBPDE5A
SCHEMBL13188337 0.80 KAT6A (0.60) HDAC8POLBHDAC1HDAC6MEN1
SCHEMBL8403540 0.78 BRD4 (0.62) POLBKDM4ETDP1ALOX15TSHR
SCHEMBL1142172 0.78 P2RX7 (0.74) POLBKDM4ETDP1ALOX15TSHR
SCHEMBL3404623 0.78 POLB (0.61) POLBKDM4ETDP1ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019180653-A1 COMPOSITIONS, MATERIALS, AND METHODS FOR DEACTIVATING TOXIC AGENTS INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (INSTEM) (IN) 2019-09-26 WO disclosed
EP-2074240-A2 METHOD OF INHIBITING CORROSION IN STORAGE AND TRANSPORT VESSELS Nalco Company (US) 2009-07-01 EP disclosed
WO-2008060782-A2 METHOD OF INHIBITING CORROSION IN STORAGE AND TRANSPORT VESSELS NALCO COMPANY (US) 2008-05-22 WO disclosed
US-20080083435-A1 METHOD OF INHIBITING CORROSION IN STORAGE AND TRANSPORT VESSELS ECOLAB USA INC. 2008-04-10 US disclosed