Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | ELANE | P08246 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454157 | 1.00 | LMNA (0.55) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL4454166 | 1.00 | LMNA (0.55) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL6982352 | 0.94 | ELANE (0.58) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL918946 | 0.91 | LMNA (0.50) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL7410333 | 0.84 | ELANE (0.50) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL7409920 | 0.83 | MAPT (0.46) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL9132892 | 0.83 | LMNA (0.46) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL269329 | 0.80 | LMNA (0.80) | LMNAELANEMAPTALDH1A1GAA | |
| SCHEMBL14760365 | 0.78 | LMNA (0.76) | LMNAELANEMAPTALDH1A1GAA | |
| Lithium SCHEMBL30522746 | 0.78 | LMNA (0.76) | LMNAELANEMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227635-B2 | Apparatus and method for carrying out multiple reactions | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-8227635-B2 | Apparatus and method for carrying out multiple reactions | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-8227635-B2 | Apparatus and method for carrying out multiple reactions | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-20090299102-A1 | APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090299102-A1 | APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090299102-A1 | APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090299102-A1 | APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS | DDO, APEX1, MMAB | LMNA 2480/4885ELANE 2937/4885MAPT 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.