Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.38 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.38 |
| ▸ | INPP5B | P32019 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloroglucinol SCHEMBL4186093 | 1.00 | BACE1 (0.61) | BACE1CA12CA9CA2CA14 | |
| Phloroglucinol SCHEMBL4179027 | 1.00 | BACE1 (0.61) | BACE1CA12CA9CA2CA14 | |
| SCHEMBL6395721 | 0.81 | BACE1 (0.47) | BACE1CA12CA9CA2CA14 | |
| Pyrophosphoric Acid SCHEMBL4179033 | 0.81 | FDPS (0.59) | BACE1CA12CA9CA2CA14 | |
| Resorcinol SCHEMBL133535 | 0.81 | ALDH1A1 (0.71) | CA12CA9CA2CA14CA1 | |
| Resorcinol SCHEMBL130699 | 0.81 | ALDH1A1 (0.71) | CA12CA9CA2CA14CA1 | |
| Resorcinol SCHEMBL20854530 | 0.78 | ALDH1A1 (0.67) | CA12CA9CA2CA14CA1 | |
| Phosphoric Acid SCHEMBL28506645 | 0.78 | ALDH1A1 (0.72) | BACE1ACHELMNAALDH1A1CYP3A4 | |
| Resorcinol SCHEMBL14717919 | 0.78 | CA12 (0.67) | CA12CA9CA2CA14CA1 | |
| Phloroglucinol SCHEMBL26311 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10877035-B2 | Advanced drug development and manufacturing | ICAGEN, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| US-20150309021-A1 | Advanced Drug Development and Manufacturing | LOS ALAMOS NATIONAL SECURITY, LLC | 2015-10-29 | — | — | US | disclosed |
| EP-2511844-B1 | X-ray microscope | XRPRO SCIENCES INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2511844-A2 | Advanced drug development and manufacturing | Los Alamos National Security, LLC (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2084519-B1 | X-RAY FLUORESCENCE ANALYSIS METHOD | LOS ALAMOS NAT SECURITY LLC (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2084519-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | Los Alamos National Security, LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008127291-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2008-10-23 | — | — | WO | disclosed |
| US-20080220441-A1 | Advanced drug development and manufacturing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | disclosed |
| US-7205345-B2 | Blend of a styrene resin, phenolic resin and phosphazene compound; heat resistance | POLYPLASTICS CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| US-7169836-B2 | Mixture of a phosphazene compound, polyphenylene ether , styrene resin and organonitrogen compound | POLYPLASTICS CO., LTD (JP) | 2007-01-30 | — | — | US | disclosed |
| US-20050148701-A1 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2005-07-07 | — | — | US | disclosed |
| US-20040147646-A1 | Flame-retardant resin composition | POLYPLASTICS CO., LTD. (JP) | 2004-07-29 | — | — | US | disclosed |