Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | INPPL1 | O15357 | 8/20 | 0.43 |
| ▸ | INPP5A | Q14642 | 4/20 | 0.43 |
| ▸ | INPP5B | P32019 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA7 | P43166 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triphosphate SCHEMBL4186099 | 0.89 | FDPS (0.45) | FDPSBLMTDP1BACE1INPPL1 | |
| Pyrophosphoric Acid SCHEMBL140572 | 0.85 | ALDH1A1 (0.57) | FDPSBLMTDP1INPPL1INPP5A | |
| Pyrophosphoric Acid SCHEMBL130700 | 0.85 | ALDH1A1 (0.57) | FDPSBLMTDP1INPPL1INPP5A | |
| Pyrophosphoric Acid SCHEMBL28255874 | 0.83 | ALDH1A1 (0.55) | FDPSBLMTDP1INPPL1INPP5A | |
| Pyrophosphoric Acid SCHEMBL27450464 | 0.83 | CYP3A4 (0.55) | FDPSBLMTDP1INPPL1INPP5A | |
| Pyrophosphoric Acid SCHEMBL1245248 | 0.82 | BLM (0.59) | FDPSBLMTDP1INPPL1INPP5A | |
| Phloroglucinol SCHEMBL4179027 | 0.81 | BACE1 (0.61) | BACE1INPPL1INPP5AINPP5BLCK | |
| Phloroglucinol SCHEMBL4186093 | 0.81 | BACE1 (0.61) | BACE1INPPL1INPP5AINPP5BLCK | |
| Phloroglucinol SCHEMBL4454766 | 0.81 | BACE1 (0.61) | BACE1INPPL1INPP5AINPP5BLCK | |
| Pyrophosphoric Acid SCHEMBL28099108 | 0.80 | FDPS (0.91) | FDPSBLMTDP1INPPL1INPP5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114464912-A | Battery cooling assembly and manufacturing method thereof | 英威达纺织（英国）有限公司 | 2022-05-10 | — | — | CN | disclosed |
| US-20090098589-A1 | Method | DUPONT NUTRITION BIOSCIENCES APS (DK) | 2009-04-16 | — | — | US | disclosed |
| EP-1888771-A2 | METHOD FOR DETERMINING PHYTASE ACTIVITY | DANISCO A/S (DK) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006123254-A2 | METHOD FOR DETERMINING PHYTASE ACTIVITY | DANISCO A/S (DK) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090098589-A1 | Method | ALPL, PPA1, ITPA | FDPS 176/4885BLM 3653/4885TDP1 1661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.