SCHEMBL445494

SCHEMBL445494

CC(=CCCc1cccc(-c2ccccc2)c1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 2/20 0.49
GPR84 Q9NQS5 1/20 0.45
BCL2 P10415 1/20 0.44
AOC3 Q16853 3/20 0.43
GRIK1 P39086 1/20 0.41
PLAAT3 P53816 1/20 0.41
PLAAT5 Q96KN8 1/20 0.41
PLAAT2 Q9NWW9 1/20 0.41
PLAAT4 Q9UL19 1/20 0.41
CYP2C9 P11712 1/20 0.41
FFAR1 O14842 3/20 0.41
FFAR4 Q5NUL3 2/20 0.41
IDH1 O75874 1/20 0.41
AKR1B1 P15121 1/20 0.41
PTGES O14684 1/20 0.41
PTGS2 P35354 2/20 0.40
ACMSD Q8TDX5 1/20 0.40
LIPG Q9Y5X9 1/20 0.40
NR4A2 P43354 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1921015 1.00 GPR52 (0.49) GPR52GPR84BCL2AOC3GRIK1
SCHEMBL1920269 0.86 FFAR1 (0.51) GPR52GRIK1FFAR1
SCHEMBL1920266 0.86 FFAR1 (0.51) GPR52GRIK1FFAR1
SCHEMBL197322 0.85 GRIK1 (0.53) GPR52GRIK1CYP2C9
SCHEMBL197321 0.85 GRIK1 (0.53) GPR52GRIK1CYP2C9
SCHEMBL15733040 0.84 PTGS2 (0.48) GPR52GPR84BCL2AOC3PLAAT3
SCHEMBL19656182 0.83 TAAR1 (0.46) FFAR1FFAR4PTGES
SCHEMBL679743 0.83 GPR52 (0.49) GPR52GPR84FFAR4
SCHEMBL1137523 0.83 CHRM2 (0.47)
SCHEMBL12003262 0.83 GPR52 (0.49) GPR52GPR84FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121802-B1 HIGH REFRACTIVE INDEX SILOXANE INSERT MATERIALS FOR EMBEDDED CONTACT LENSES ALCON INC (CH) 2024-07-17 EP claimed
EP-3728339-B1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS AMO Ireland (IE) 2022-07-06 EP claimed
EP-2303331-B1 OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME ALCON INC (CH) 2022-01-26 EP claimed
EP-3200840-B1 LOW-WATER CONTENT ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES ALCON INC (CH) 2021-11-17 EP claimed
US-10756139-B2 Organic light emitting display SAMSUNG SDI CO., LTD. (KR) 2020-08-25 US claimed
US-10727443-B2 Organic light emitting display SAMSUNG SDI CO., LTD. (KR) 2020-07-28 US claimed
EP-3200839-B1 HYDROPHOBIC ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES NOVARTIS AG (CH) 2019-09-04 EP claimed
EP-3223870-B1 WET-PACK INTRAOCULAR LENS MATERIALS WITH HIGH REFRACTIVE INDEX NOVARTIS AG (CH) 2018-09-26 EP claimed
US-20180158879-A1 ORGANIC LIGHT EMITTING DISPLAY SAMSUNG SDI CO., LTD. (KR) 2018-06-07 US claimed
EP-3077016-B1 SOFT ACRYLIC MATERIALS WITH HIGH REFRACTIVE INDEX AND MINIMIZED GLISTENING NOVARTIS AG (CH) 2018-05-16 EP claimed
US-20110281995-A1 Polycarbonate Resin Composition and Molded Product Using the Same CHEIL INDUSTRIES INC. (KR) 2011-11-17 US claimed
EP-2341102-A1 Thermoplastic resin composition revealing improved impact strength and melt flow property Cheil Industries Inc. (KR) 2011-07-06 EP claimed
US-20110160377-A1 Thermoplastic Resin Composition Having Improved Impact Strength and Melt Flow Properties CHEIL INDUSTRIES INC. (KR) 2011-06-30 US claimed
EP-2225325-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2011-06-01 EP claimed
US-20100160559-A1 Polylactic Acid/Polycarbonate Resin Composition and Molded Product Made Using the Same CHEIL INDUSTRIES INC. (KR) 2010-06-24 US claimed
EP-2199342-A2 Polylactic acid/polycarbonate resin composition and molded product made using the same Cheil Industries Inc. (KR) 2010-06-23 EP claimed
EP-1080382-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2009-07-08 EP claimed
EP-1664855-B1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB (US) 2009-03-11 EP claimed
EP-1177227-B1 WATER PLASTICIZED HIGH REFRACTIVE INDEX POLYMER FOR OPHTHALMIC APPLICATIONS SURGIDEV CORP (US) 2003-10-01 EP claimed
EP-0914169-B1 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LAB INC (US) 2003-07-30 EP claimed