SCHEMBL4455462

SCHEMBL4455462

O=C1[CH]CC(=O)c2ccccc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.48
MAOB P27338 4/20 0.48
CDC25B P30305 3/20 0.48
IDO1 P14902 3/20 0.48
SNCA P37840 2/20 0.48
AKT1 P31749 1/20 0.48
MAP2K1 Q02750 1/20 0.48
PIN1 Q13526 1/20 0.48
EHMT2 Q96KQ7 1/20 0.48
NSD1 Q96L73 1/20 0.48
EHMT1 Q9H9B1 1/20 0.48
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
S100A4 P26447 4/20 0.39
CES1 P23141 3/20 0.38
BCHE P06276 2/20 0.38
PLIN1 O60240 2/20 0.38
LMNA P02545 2/20 0.38
MAPT P10636 2/20 0.38
MAPK1 P28482 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20366857 0.76 CDC25B (0.56) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL1450360 0.75 MEN1 (0.39) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL57446 0.75 MAOA (0.46) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL9768584 0.70 CA1 (0.42) CDC25BIDO1PIN1MEN1KMT2A
SCHEMBL855431 0.69 MAOA (0.56) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL29385474 0.69 MAOA (0.56) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL88188 0.69 CES1 (0.52) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL29353628 0.69 CES1 (0.52) MAOAMAOBCDC25BIDO1SNCA
SCHEMBL28905016 0.68 PTPRC (0.45) MAOAMAOBCDC25BIDO1SNCA
Water SCHEMBL460840 0.67 MAOA (0.54) MAOAMAOBCDC25BIDO1SNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106456824-A Heterogeneous block comprising foam 宝洁公司 2017-02-22 CN disclosed
CN-106456825-A Heterogeneous block comprising foam 宝洁公司 2017-02-22 CN disclosed
CN-104040385-A Retardation film, method for producing retardation film, polarizing plate, and liquid crystal display device KONICA MINOLTA INC 2014-09-10 CN disclosed
CN-103975260-A Polarizing plate and liquid crystal display device KONICA MINOLTA INC 2014-08-06 CN disclosed
CN-103518151-A Retardation film, polarizing plate, liquid crystal display device, and compound KONICA MINOLTA ADVANCED LAYERS 2014-01-15 CN disclosed
CN-103314315-A Optical film, and polarizing plate and liquid crystal display device using same KONICA MINOLTA OPTO INC 2013-09-18 CN disclosed
CN-103064143-A Optical compensation film, method for producing same, polarizing plate, and liquid crystal display device KONICA MINOLTA OPTO INC 2013-04-24 CN disclosed
CN-1841092-B Optical film KONICA MINOLTA OPTO INC 2012-11-28 CN disclosed
US-8293341-B2 Cellulose ester film, retardation film, polarizing plate and liquid crystal display device FUJIFILM CORPORATION (JP) 2012-10-23 US disclosed
CN-101939673-B Retardation film KONICA MINOLTA OPTO INC 2012-08-08 CN disclosed
US-7005440-B1 Therapeutic uses of tri-aryl acid derivatives AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2006-02-28 US disclosed
CN-1619344-A Polarizing plate and display device KONICA MINOLTA OPTO INC (JP) 2005-05-25 CN disclosed
US-20030220373-A1 Therapeutic uses of PPAR mediators AVENTIS PHARMACEUTICALS PRODUCTS INC. 2003-11-27 US disclosed
US-6635655-B1 Agonists or antagonists of peroxisome proliferator-activated receptors AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-10-21 US disclosed
EP-1267874-A2 THERAPEUTIC USES OF PPAR MEDIATORS Aventis Pharma Deutschland GmbH (DE) 2003-01-02 EP disclosed
EP-1177176-A1 TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS Aventis Pharma Deutschland GmbH (DE) 2002-02-06 EP disclosed
EP-1177187-A1 DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS Aventis Pharma Deutschland GmbH (DE) 2002-02-06 EP disclosed
WO-2001066098-A2 THERAPEUTIC USES OF PPAR MEDIATORS AVENTIS PHARMA DEUTSCHLAND GMBH 2001-09-13 WO disclosed
WO-2000064888-A1 DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-11-02 WO disclosed
WO-2000064876-A1 TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-11-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030220373-A1 Therapeutic uses of PPAR mediators PPARG, PPARA, PPARD MAOA 4510/4885MAOB 4292/4885CDC25B 4270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.