Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736314 | 0.82 | — | — | |
| SCHEMBL3572466 | 0.78 | — | — | |
| SCHEMBL4454599 | 0.78 | DAO (0.37) | DHODH | |
| SCHEMBL4648799 | 0.73 | PTPN1 (0.38) | DDB1CRBN | |
| SCHEMBL629366 | 0.72 | PTPN1 (0.59) | DDB1CRBN | |
| SCHEMBL14299363 | 0.67 | CYP1A2 (0.53) | TPSAB1 | |
| SCHEMBL27873878 | 0.60 | CYP1A2 (0.51) | TPSAB1 | |
| SCHEMBL9975454 | 0.60 | ADRB2 (0.44) | — | |
| SCHEMBL629274 | 0.59 | PTPN1 (0.60) | — | |
| SCHEMBL630220 | 0.59 | BCHE (0.37) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |