Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.63 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.54 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.54 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13708632 | 1.00 | SMN1; SMN2 (0.69) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL27892099 | 0.98 | SMN1; SMN2 (0.72) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL13544566 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL14963068 | 0.92 | SMN1; SMN2 (0.77) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL15480466 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL28658599 | 0.89 | SMN1; SMN2 (0.88) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL6549000 | 0.88 | SMN1; SMN2 (0.84) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL10015691 | 0.86 | ALDH1A1 (0.80) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL7699918 | 0.85 | SMN1; SMN2 (0.67) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL12820363 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931327-B1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2016-08-17 | — | — | EP | disclosed |
| EP-1931327-B1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2016-08-17 | — | — | EP | disclosed |
| CN-104744234-A | Cyclopropyl compounds and compositions for delivering active agents | MISPHERE TECH INC | 2015-07-01 | — | — | CN | disclosed |
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| CN-101522627-A | Cyclopropyl compounds and compositions for delivery of active agents | EMISPHERE TECH INC (US) | 2009-09-02 | — | — | CN | disclosed |
| EP-1931327-A2 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | Emisphere Technologies, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007022532-A2 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007022532-A2 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | PAICS, ABCB4, ABCB11 | SMN1; SMN2 71/4885HDAC3 1471/4885HDAC1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.