Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.53 |
| ▸ | TACR3 | P29371 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28619856 | 0.83 | ACHE (0.56) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL1259674 | 0.79 | ACHE (0.59) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL27917367 | 0.79 | DHODH (0.58) | ACHETACR3LMNASMN1; SMN2HPGD | |
| SCHEMBL27367367 | 0.79 | ACHE (0.51) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL11172886 | 0.78 | KDM4E (0.55) | ACHELMNASMN1; SMN2KDM4EPDE10A | |
| SCHEMBL10671292 | 0.78 | PDE10A (0.58) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL20809331 | 0.78 | ACHE (0.50) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL8675109 | 0.78 | ACHE (0.50) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL9988793 | 0.78 | DHODH (0.53) | ACHETACR3LMNASMN1; SMN2KDM4E | |
| SCHEMBL8091105 | 0.78 | ACHE (0.54) | ACHELMNASMN1; SMN2KDM4EPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598390-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2009-10-06 | — | — | US | disclosed |
| US-20060263844-A1 | Flourescent chemical compounds having high selectivity for double standard DNA, and methods for their use | MOLECULAR PROBES, INC. | 2006-11-23 | — | — | US | disclosed |