Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456355 | 1.00 | PDE7A (0.45) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL4456357 | 0.89 | PDE7A (0.44) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL6556669 | 0.81 | PDE7A (0.56) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL5878921 | 0.70 | PDE7A (0.61) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL27581742 | 0.70 | PDE7A (0.75) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL6815838 | 0.69 | PDE7A (0.56) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL11292200 | 0.65 | TDP1 (0.38) | LMNAKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6811842 | 0.65 | PDE7A (0.51) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL7605579 | 0.65 | PDE7A (0.67) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL11024226 | 0.65 | PDE7A (0.58) | PDE7APDE4BPDE4DPDE7BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090317476-A1 | COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH A LEUKOTRIENE RECEPTOR ANTAGONIST FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE | EPIGENESIS PHARMACEUTICALS, LLC | 2009-12-24 | — | — | US | disclosed |
| EP-1653910-A2 | COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH A LEUKOTRIENE RECEPTOR ANTAGONIST FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE | Epigenesis Pharmaceuticals LLC (US) | 2006-05-10 | — | — | EP | disclosed |
| US-20050101544-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease | EPIGENESIS PHARMACEUTICALS, LLC | 2005-05-12 | — | — | US | disclosed |
| WO-2005011595-A2 | COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH A LEUKOTRIENE RECEPTOR ANTAGONIST FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE | EPIGENESIS PHARMACEUTICALS LLC (US) | 2005-02-10 | — | — | WO | disclosed |
| US-20050026882-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease | EPIGENESIS PHARMACEUTICALS LLC | 2005-02-03 | — | — | US | disclosed |
| US-5446058-A | Leukotriene antagonists, 5-alpha-reductase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0463638-B1 | Aminophenyl derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0173516-B1 | (Fused)benz(thio)amides | ONO PHARMACEUTICAL CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0463638-A1 | Aminophenyl derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-01-02 | — | — | EP | disclosed |
| US-4939141-A | (Fused) benz (thio) amides and pharmaceutical compositions, thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| US-4847275-A | ENZYME INHIBITOR, LEUKOTRIENE ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-07-11 | — | — | US | disclosed |
| US-4780469-A | (Fused) benz(thio)amides and pharmaceutical use | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-10-25 | — | — | US | disclosed |
| EP-0173516-A2 | (Fused)benz(thio)amides | ONO PHARMACEUTICAL CO., LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101544-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease | LTB4R, LTB4R2, CYSLTR1 | PDE7A 231/4885PDE4B 1027/4885PDE4D 1038/4885 |
| US-20050026882-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease | LTB4R2, LTB4R, CYSLTR2 | PDE7A 239/4885PDE4B 980/4885PDE4D 990/4885 |
| US-20090317476-A1 | COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH A LEUKOTRIENE RECEPTOR ANTAGONIST FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE | LTB4R, LTB4R2, CYSLTR1 | PDE7A 231/4885PDE4B 1027/4885PDE4D 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.