SCHEMBL4456435

SCHEMBL4456435

Nc1cc(S(=O)(=O)O)c2ccccc2c1N.[NaH]

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SENP2 Q9HC62 5/20 0.56
SENP1 Q9P0U3 4/20 0.56
SUMO2 P61956 4/20 0.56
SUMO1 P63165 4/20 0.56
SENP7 Q9BQF6 4/20 0.56
TTR P02766 1/20 0.55
SENP3 Q9H4L4 2/20 0.54
MEN1 O00255 1/20 0.54
ALDH1A1 P00352 1/20 0.54
APP P05067 1/20 0.54
MAPT P10636 1/20 0.54
THRB P10828 1/20 0.54
HPGD P15428 1/20 0.54
ALOX12 P18054 1/20 0.54
SNCA P37840 1/20 0.54
RECQL P46063 1/20 0.54
BLM P54132 1/20 0.54
KMT2A Q03164 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
SLC7A11 Q9UPY5 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31222829 0.98 SENP2 (0.58) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL1891641 0.98 SENP2 (0.58) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL7965173 0.85 TTR (0.55) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL5677307 0.85 SENP2 (0.59) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL18937495 0.84 SENP2 (0.56) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL4113734 0.84 NT5E (0.57) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL8421029 0.83 TTR (0.56) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL6051324 0.83 TTR (0.56) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL153735 0.81 NT5E (0.59) SENP2SENP1SUMO2SUMO1SENP7
SCHEMBL6938480 0.81 TTR (0.55) SENP2SENP1SUMO2SUMO1SENP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009083612-A2 FLAVONOID AS MEANS FOR THE PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE AND OTHER PROTEIN FOLDING-ABERRATION DISEASES GROSCHUP MARTIN H (DE) 2009-07-09 WO disclosed