Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | CCR5 | P51681 | 7/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440416 | 0.88 | HTR7 (0.56) | HTR7DRD2HTR1DDRD3CCR5 | |
| SCHEMBL21540591 | 0.76 | SMN1; SMN2 (0.49) | CCR5 | |
| SCHEMBL14520864 | 0.74 | HTR7 (0.53) | HTR7DRD2HTR1DDRD3CCR5 | |
| SCHEMBL2729765 | 0.74 | HTR7 (0.74) | HTR7DRD2HTR1DDRD3CCR5 | |
| Sb-258719 SCHEMBL2471089 | 0.74 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3CCR5 | |
| Sb-258719 SCHEMBL29774472 | 0.74 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3CCR5 | |
| Sb-258719 SCHEMBL2471088 | 0.74 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3CCR5 | |
| Sb-258719 SCHEMBL3688509 | 0.73 | HTR7 (0.98) | HTR7DRD2HTR1DDRD3CCR5 | |
| SCHEMBL28700710 | 0.72 | ACHE (0.49) | HTR7DRD2HTR1DDRD3SIGMAR1 | |
| SCHEMBL14375268 | 0.71 | MEN1 (0.63) | HTR7SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2052251-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008013556-A1 | COMBINATION 5-HT7 RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR THERAPY | JANSSEN PHARMACEUTICAL N.V. (BE) | 2008-01-31 | — | — | WO | disclosed |