Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 14/20 | 0.74 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | HTR1D | P28221 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sb-258719 SCHEMBL2471088 | 0.81 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3HTR2A | |
| Sb-258719 SCHEMBL29774472 | 0.81 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3HTR2A | |
| Sb-258719 SCHEMBL2471089 | 0.81 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3HTR2A | |
| Sb-258719 SCHEMBL3688509 | 0.80 | HTR7 (0.98) | HTR7DRD2HTR1DDRD3HTR2A | |
| SCHEMBL4456846 | 0.74 | HTR7 (0.58) | HTR7DRD2HTR1DDRD3SIGMAR1 | |
| SCHEMBL8553908 | 0.73 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3HTR2A | |
| Hydrochloric Acid SCHEMBL8593597 | 0.73 | HTR7 (0.98) | HTR7DRD2HTR1DDRD3HTR2A | |
| SCHEMBL3945353 | 0.72 | HTR7 (0.49) | HTR7DRD2HTR1DDRD3HTR2A | |
| SCHEMBL5440416 | 0.72 | HTR7 (0.56) | HTR7DRD2HTR1DDRD3SIGMAR1 | |
| SCHEMBL8552181 | 0.72 | HTR7 (0.77) | HTR7DRD2HTR1DDRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058769-A1 | METHOD OF TREATING MUCOSAL INFLAMMATION | MCMASTER UNIVERSITY (CA) | 2012-05-10 | — | — | WO | disclosed |
| EP-2049090-A1 | USE OF 5-HT7 RECEPTOR AGONISTS FOR THE TREATMENT OF PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008000495-A1 | USE OF 5-HT7 RECEPTOR AGONISTS FOR THE TREATMENT OF PAIN | LABORATORIOS DEL DR. ESTEVE, S.A (ES) | 2008-01-03 | — | — | WO | disclosed |