Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461703 | 0.75 | KCNA5 (0.43) | CYP19A1KCNA5MAPTNOTUMALDH1A1 | |
| SCHEMBL4456913 | 0.72 | KCNA5 (0.44) | KCNA5MAPT | |
| SCHEMBL4458827 | 0.72 | CYP19A1 (0.43) | CYP19A1RORCKCNA5MAPTCYP3A4 | |
| SCHEMBL4459578 | 0.70 | KCNA5 (0.43) | CYP19A1KCNA5MAPTNOTUMALDH1A1 | |
| SCHEMBL789630 | 0.68 | TRPV1 (0.57) | MAPTNOTUMMAPK1 | |
| SCHEMBL789977 | 0.68 | HTT (0.61) | MAPTNOTUMMAPK1CYP3A4ALDH1A1 | |
| SCHEMBL27879611 | 0.67 | CYP19A1 (0.47) | CYP19A1KCNA5MAPTHCRTR1HCRTR2 | |
| SCHEMBL13971458 | 0.67 | ELOVL1 (0.42) | KCNA5MAPTCYP3A4POLB | |
| SCHEMBL12139578 | 0.64 | MAPT (0.49) | CYP19A1MAPTMAPK1ALPLALDH1A1 | |
| SCHEMBL18783191 | 0.64 | KIF11 (0.56) | CYP19A1MAPTCYP3A4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | CYP19A1 4359/4885RORC 3636/4885KCNA5 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.