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Desonide

Desonide

SCHEMBL4457124

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCCCC(=O)O.C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Desonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.63
▸ CYP3A4 P08684 8/20 0.63
▸ HIF1A Q16665 6/20 0.63
▸ PGR P06401 5/20 0.63
▸ LMNA P02545 3/20 0.63
▸ NR1I2 O75469 1/20 0.63
▸ HSD17B10 Q99714 3/20 0.56
▸ TSHR P16473 3/20 0.56
▸ NFKB1 P19838 3/20 0.56
▸ AR P10275 3/20 0.56
▸ NPSR1 Q6W5P4 3/20 0.56
▸ PMP22 Q01453 2/20 0.56
▸ NR3C2 P08235 2/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ CYP2D6 P10635 1/20 0.56
▸ KMT2A Q03164 1/20 0.56
▸ APEX1 P27695 1/20 0.56
▸ IKBKB O14920 1/20 0.56
▸ CHUK O15111 1/20 0.56
▸ ADRB2 P07550 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Desonide SCHEMBL11778722 0.92 CYP3A4 (0.73) CYP3A4NR3C1HIF1APGRLMNA
Desonide SCHEMBL2115498 0.87 CYP3A4 (0.75) CYP3A4NR3C1HIF1APGRLMNA
Flunisolide SCHEMBL20915050 0.84 CYP3A4 (0.69) CYP3A4NR3C1HIF1APGRLMNA
Triamcinolone Acetonide SCHEMBL238067 0.84 LMNA (0.84) CYP3A4NR3C1HIF1APGRLMNA
Triamcinolone Acetonide SCHEMBL28103100 0.84 CYP3A4 (0.87) CYP3A4NR3C1HIF1APGRLMNA
Dexbudesonide SCHEMBL4260550 0.83 CYP3A4 (0.73) CYP3A4NR3C1HIF1APGRLMNA
Dexbudesonide SCHEMBL18695366 0.83 CYP3A4 (0.73) CYP3A4NR3C1HIF1APGRLMNA
Triamcinolone Acetonide SCHEMBL9987506 0.83 CYP3A4 (0.75) CYP3A4NR3C1HIF1APGRLMNA
Triamcinolone Acetonide SCHEMBL10944236 0.83 LMNA (0.83) CYP3A4NR3C1HIF1APGRLMNA
Desonide SCHEMBL9861716 0.83 NR3C1 (0.83) CYP3A4NR3C1HIF1APGRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009059191-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION EVERETT LABORATORIES, INC. (US) 2009-05-07 — — WO disclosed
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