Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flunisolide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.69 |
| ▸ | PGR | P06401 | 8/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | AR | P10275 | 5/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flunisolide SCHEMBL9987242 | 0.95 | CYP3A4 (0.61) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Triamcinolone Acetonide SCHEMBL20915153 | 0.95 | HIF1A (0.77) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Flunisolide SCHEMBL221433 | 0.92 | PGR (0.73) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Desonide SCHEMBL11778722 | 0.92 | CYP3A4 (0.73) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Fluocinolone Acetonide SCHEMBL5501859 | 0.90 | HIF1A (0.77) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Triamcinolone Acetonide SCHEMBL28103100 | 0.89 | CYP3A4 (0.87) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Desonide SCHEMBL2115498 | 0.87 | CYP3A4 (0.75) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Fluocinolone Acetonide SCHEMBL2251974 | 0.86 | NR3C1 (0.82) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Triamcinolone Acetonide SCHEMBL5457484 | 0.85 | CYP3A4 (0.69) | CYP3A4PGRNR3C1HIF1ALMNA | |
| Fluocinolone Acetonide SCHEMBL8450831 | 0.85 | NR3C1 (0.77) | CYP3A4PGRNR3C1HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11226341-B2 | Method of treating asthma using an IL-13 antibody | GENENTECH, INC. (US) | 2022-01-18 | — | — | US | disclosed |
| US-20190120854-A1 | DIAGNOSIS AND TREATMENTS RELATING TO TH2 INHIBITION | GENENTECH INC (US) | 2019-04-25 | — | — | US | disclosed |