Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825175 | 0.81 | ALDH1A1 (0.33) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL28019025 | 0.80 | MAPT (0.34) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL4262537 | 0.80 | MAPT (0.33) | NPC1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9149341 | 0.67 | SMN1; SMN2 (0.35) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL6657774 | 0.67 | L3MBTL1 (0.37) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL9001396 | 0.65 | HTT (0.36) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL28359455 | 0.64 | NPC1 (0.37) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL22682960 | 0.64 | HTT (0.35) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL29091452 | 0.64 | NPC1 (0.40) | NPC1L3MBTL1CES2CES1ALDH1A1 | |
| SCHEMBL27825782 | 0.64 | MAPT (0.33) | NPC1L3MBTL1CES2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101065391-B | C-aryl glucoside sglt2 inhibitors and method | BRISTOL MYERS SQUIBB CO | 2011-07-27 | — | — | CN | disclosed |
| EP-1791852-B8 | C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND METHOD FOR THEIR PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-04-01 | — | — | EP | disclosed |
| CN-101065391-A | C-aryl glucoside sglt2 inhibitors and method | BRISTOL MYERS SQUIBB CO (US) | 2007-10-31 | — | — | CN | disclosed |
| EP-1791852-A2 | C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND METHOD FOR THEIR PRODUCTION | Brystol-Myers Squibb Company (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006034489-A2 | C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND METHOD FOR THEIR PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-03-30 | — | — | WO | disclosed |